When a vampire destroyed decades ago by professor Trevor "Broom" Bruttenholm is resurrected, supernatural agents Hellboy, Liz Sherman and Abe Sapien must pool their resources to stop a demon uprising. As the team battles hordes of ghosts and hellhounds, a showdown brews between Hellboy and Hecate, queen of the witches. Ron Perlman, Selma Blair and John Hurt lend their voices to this animated adventure based on Mike Mignola's comic-book series.