Colossal canine Clifford (voiced by the late John Ritter) lives with his wonderful owners, the Howard family, whom he loves. But soon, the lovable red dog wonders whether his oversized stature is becoming a burden on his family. Hoping to rid them of the responsibility, Clifford joins a traveling animal circus with his buddies Cleo (voiced by Cree Summer) and T-Bone (voiced by Kel Mitchell).