Recognizing that they're powerless to stop vampire hunter Blade (Wesley Snipes), the vampires who rule the human race set up Blade to look like a serial killer, immediately prompting the FBI to go after him and put him behind bars. But more trouble brews: Just as Blade realizes he's being pursued, Dracula (Dominic Purcell), the biggest bloodsucker of all time, is released, forcing Blade to enlist the help of a dream team of vampire killers.