The orphaned Fitzgerald sisters (Katherine Isabelle and Emily Perkins) trek across the Canadian wilderness during the 19th century. After visiting an Indian campsite and receiving a prophetic warning, the girls take refuge at a trading fort populated only by men. Soon, they learn of werewolves outside the walls. When Ginger is bitten and starts slowly changing, the sisters realize they must work to decipher the prophecy before it's too late.