It's all about chemistry when uptight New Yorker Alex Whitman (Matthew Perry) and blithe-spirited Isabel Fuentes (Salma Hayek) spend one passionate night together in Las Vegas just hours after meeting. The next morning, they go their separate ways and don't see each other until three months later -- when Isabel realizes she's pregnant. Alex and Isabel decide to get married, but the honeymoon ends when their families meet and cultures clash.