Domestic detectives Nick and Nora Charles (beloved on-screen duo William Powell and Myrna Loy) are back for the second installment of their murder-mystery series, this time to help Nora's cousin Selma (Elissa Landi) find her missing husband, Robert. With the help of Selma's lovesick friend David (Jimmy Stewart), the Charleses track a trail of dead bodies that reveals Robert's secret life and leads to an unlikely killer.